Recombination in the mammalian germ line
作者： D PITTMAN , J SCHIMENTI
DOI: 10.1016/S0070-2153(08)60170-2
关键词:
摘要: Elucidation of meiotic recombination mechanisms in mammals faces many obstacles. Much our understanding has been built upon studies the fungi, which have served to guide experimental design mammalian cells and mice. A clearer picture is now emerging reveals that general principles are conserved across this evolutionary divide. number genes critical yeast also exist mammals. Transgenic technologies, addition advances molecular biology, provide several strategies investigate properties regulation recombination. This chapter reviews current state knowledge regarding germ line, covering topics such as gene conversion, mechanics, recombination-based genetic mutation, crossing over, involved
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