Green synthesis of isopropyl myristate in novel single phase medium Part I: Batch optimization studies.

摘要: Isopropyl myristate finds many applications in food, cosmetic and pharmaceutical industries as an emollient, thickening agent, or lubricant. Using a homogeneous reaction phase, non-specific lipase derived from Candida antartica, marketed Novozym 435, was determined to be most suitable for the enzymatic synthesis of isopropyl myristate. The high molar ratio alcohol acid creates novel single phase medium which overcomes mass transfer effects facilitates downstream processing. effect various parameters optimized obtain yield Effect temperature, agitation speed, organic solvent, biocatalyst loading batch operational stability enzyme systematically studied. conversion 87.65% obtained when myristic (15:1) used with 4% (w/w) catalyst speed 150 rpm at 60 °C. has also shown good under conditions.