A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy.
作者： Simon Denus , Fannie Mottet , Sandra Korol , Yassamin Feroz Zada , Sylvie Provost
DOI: 10.1002/EHF2.12934
关键词:
摘要: AIMS Few investigations have been conducted to identify genetic determinants of common, polygenetic forms heart failure (HF), and only a limited number these associations validated by multiple groups. METHODS AND RESULTS We performed case-control study further investigate the potential impact 14 previously reported candidate genes on risk HF specific sub-types. also an exploratory genome-wide study. included 799 patients with 1529 controls. After adjusting for age, sex, ancestry, we found that C allele rs2234962 in BAG3 was associated decreased idiopathic dilated cardiomyopathy (odds ratio 0.42, 95% confidence interval 0.25-0.68, P = 0.0005), consistent previous report. No association other primary variants or found. CONCLUSIONS Our findings provide independent replication between common coding variant (rs2234962) cardiomyopathy.
doaj.org参考文章(15)
S de Denus, J L Rouleau, D L Mann, G S Huggins, T P Cappola, S H Shah, J Keleti, Y F Zada, S Provost, A Bardhadi, M S Phillips, V Normand, I Mongrain, M-P Dubé, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials Pharmacogenomics Journal. ,vol. 17, pp. 192- 200 ,(2017) , 10.1038/TPJ.2016.4
T. P. Cappola, S. J. Matkovich, W. Wang, D. van Booven, M. Li, X. Wang, L. Qu, N. K. Sweitzer, J. C. Fang, M. P. Reilly, H. Hakonarson, J. M. Nerbonne, G. W. Dorn, Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 2456- 2461 ,(2011) , 10.1073/PNAS.1017494108
Paul L Auer, Alexander Teumer, Ursula Schick, Andrew O'Shaughnessy, Ken Sin Lo, Nathalie Chami, Chris Carlson, Simon de Denus, Marie-Pierre Dubé, Jeff Haessler, Rebecca D Jackson, Charles Kooperberg, Louis-Philippe Lemieux Perreault, Matthias Nauck, Ulrike Peters, John D Rioux, Frank Schmidt, Valérie Turcot, Uwe Völker, Henry Völzke, Andreas Greinacher, Li Hsu, Jean-Claude Tardif, George A Diaz, Alexander P Reiner, Guillaume Lettre, Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits Nature Genetics. ,vol. 46, pp. 629- 634 ,(2014) , 10.1038/NG.2962
Xiaoyi Gao, Joshua Starmer, Eden R. Martin, A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms Genetic Epidemiology. ,vol. 32, pp. 361- 369 ,(2008) , 10.1002/GEPI.20310
Eric Villard, Claire Perret, Françoise Gary, Carole Proust, Gilles Dilanian, Christian Hengstenberg, Volker Ruppert, Eloisa Arbustini, Thomas Wichter, Marine Germain, Olivier Dubourg, Luigi Tavazzi, Marie-Claude Aumont, Pascal DeGroote, Laurent Fauchier, Jean-Noël Trochu, Pierre Gibelin, Jean-François Aupetit, Klaus Stark, Jeanette Erdmann, Roland Hetzer, Angharad M. Roberts, Paul J.R. Barton, Vera Regitz-Zagrosek, Uzma Aslam, Laëtitia Duboscq-Bidot, Matthias Meyborg, Bernhard Maisch, Hugo Madeira, Anders Waldenström, Enrique Galve, John G. Cleland, Richard Dorent, Gerard Roizes, Tanja Zeller, Stefan Blankenberg, Alison H. Goodall, Stuart Cook, David A. Tregouet, Laurence Tiret, Richard Isnard, Michel Komajda, Philippe Charron, François Cambien, A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy web science. ,vol. 32, pp. 1065- 1076 ,(2011) , 10.1093/EURHEARTJ/EHR105
Thomas P. Cappola, Mingyao Li, Jing He, Bonnie Ky, Joan Gilmore, Liming Qu, Brendan Keating, Muredach Reilly, Cecelia E. Kim, Joseph Glessner, Edward Frackelton, Hakon Hakonarson, Faisel Syed, Anna Hindes, Scot J. Matkovich, Sharon Cresci, Gerald W. Dorn, Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circulation-cardiovascular Genetics. ,vol. 3, pp. 147- 154 ,(2010) , 10.1161/CIRCGENETICS.109.898395
Douglas S. Lee, Michael J. Pencina, Emelia J. Benjamin, Thomas J. Wang, Daniel Levy, Christopher J. O'Donnell, Byung-Ho Nam, Martin G. Larson, Ralph B. D'Agostino, Ramachandran S. Vasan, Association of Parental Heart Failure with Risk of Heart Failure in Offspring The New England Journal of Medicine. ,vol. 355, pp. 138- 147 ,(2006) , 10.1056/NEJMOA052948
Wendy S. Post, Martin G. Larson, Richard H. Myers, Maurizio Galderisi, Daniel Levy, Heritability of Left Ventricular Mass The Framingham Heart Study Hypertension. ,vol. 30, pp. 1025- 1028 ,(1997) , 10.1161/01.HYP.30.5.1025
Ulrike Esslinger, Sophie Garnier, Agathe Korniat, Carole Proust, Georgios Kararigas, Martina Müller-Nurasyid, Jean-Philippe Empana, Michael P. Morley, Claire Perret, Klaus Stark, Alexander G. Bick, Sanjay K. Prasad, Jennifer Kriebel, Jin Li, Laurence Tiret, Konstantin Strauch, Declan P. O'Regan, Kenneth B. Marguiles, Jonathan G. Seidman, Pierre Boutouyrie, Patrick Lacolley, Xavier Jouven, Christian Hengstenberg, Michel Komajda, Hakon Hakonarson, Richard Isnard, Eloisa Arbustini, Harald Grallert, Stuart A. Cook, Christine E. Seidman, Vera Regitz-Zagrosek, Thomas P. Cappola, Philippe Charron, François Cambien, Eric Villard, Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy PLOS ONE. ,vol. 12, ,(2017) , 10.1371/JOURNAL.PONE.0172995
Valerie D. Myers, Joseph M. McClung, JuFang Wang, Farzaneh G. Tahrir, Manish K. Gupta, Jennifer Gordon, Christopher H. Kontos, Kamel Khalili, Joseph Y. Cheung, Arthur M. Feldman, The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease. JACC: Basic to Translational Science. ,vol. 3, pp. 122- 131 ,(2018) , 10.1016/J.JACBTS.2017.09.009