A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms

作者: Xiaoyi Gao , Joshua Starmer , Eden R. Martin

DOI: 10.1002/GEPI.20310

关键词: Genetic associationType I and type II errorsBonferroni correctionFalse positive paradoxComputational biologyLinkage disequilibriumBiologyMultiple comparisons problemStatisticsSingle-nucleotide polymorphismPermutation

摘要: Multiple testing is a challenging issue in genetic association studies using large numbers of single nucleotide polymorphism (SNP) markers, many of which exhibit linkage …

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