Levels of blood-bourne factors and cytosol glucocorticoid receptors during the initiation of muscle atrophy in rodent hindlimbs

摘要: When only 1 hindlimb of the adult mouse was immobilized for 13 h, immobilization-induced failure insulin to stimulate 2-deoxyglucose uptake observed in soleus muscle. unchanged contralateral, nonimmobilized In rat, protein synthesis rates decreased one limb as compared measured contralateral same animal. The a rat with were not significantly different from muscle rats no immobilization. Specific binding of3H-dexamethasone, determined by exchange assay gastrocnemius cytosol, increased after 7 days immobilization, but 6 h Changes level blood-bourne factors or cytosolic glucocorticoid levels do themselves initiate atrophy rodent limbs.