Evaluating response to mood stabilizers in patients with mixed depression: A study of agreement between three different mania rating scales and a depression rating scale

摘要: Abstract Background The aim of the present study was to evaluate agreement between three pairs formed by one mania scales (Young Mania Rating Scale [YMRS], Bech-Rafaelsen [BRMS], or Clinician-Administered for [CARS-M]) and a single depression scale (21-item Hamilton Depression [21-HAM-D]) evaluation response mood stabilizers in patients with mixed bipolar disorder. Methods Between 2010 2014, 68 consecutive type I II outpatients as per DSM-IV-TR Cincinnati criteria were included this 8-week open-label trial randomly receive carbamazepine, lithium carbonate, valproic acid monotherapy. Results Patterns (defined reduction at least 50% on 21-HAM-D) strikingly similar: 21-HAM-D+YMRS=22.1%, 21-HAM-D+BRMS=20.6%, 21-HAM-D+CARS-M=23.5% ( p Limitations decision combine rating any assess treatment is questionable. Conclusions suggests that tested (YMRS, BRMS, CARS-M) can be combined 21-HAM-D This should give clinicians an added measure confidence using strategy until valid, specific instruments are developed assessment states.