Age-Dependent Effects of Captopril on the Arterial Baroreflex Control of Heart Rate in Conscious Lambs
作者： Michael J. Monument , Francine G. Smith
DOI: 10.1113/EPH8802602
关键词:
摘要: To test the hypothesis that angiotensin (ANG) II modulates arterial baroreflex control of heart rate (HR) in an age-dependent manner, various parameters governing HR were assessed before and after removal endogenously produced ANG by administration angiotensin-converting enzyme (ACE) inhibitor, captopril, to conscious, chronically instrumented lambs aged ~1 week (8 ± 1 days; n = 8) or ~6 weeks (46 5 8). After systolic, diastolic mean pressures decreased significantly from levels increased; however, effects greater 1- than 6-week-old lambs. In 1-week-old lambs, there was also a significant increase slope coefficient, decrease minimum point maximum gain. no captopril on any baroreflex. Therefore, we accept our conclude role modulating cardiovascular homeostasis appears be more predominant newborn later life. Experimental Physiology (2003) 88.6, 761–768.
sci-hub.se 参考文章(66)
Jaspal S. Kooner, Clive N. May, Stanley Peart, Christopher J. Mathias, Separation of peripheral and central cardiovascular actions of angiotensin II American Journal of Physiology-heart and Circulatory Physiology. ,vol. 273, ,(1997) , 10.1152/AJPHEART.1997.273.6.H2620
I. A. Reid, Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure American Journal of Physiology-endocrinology and Metabolism. ,vol. 262, ,(1992) , 10.1152/AJPENDO.1992.262.6.E763
E R Lumbers, M J Ismay, A D Stevens, The action of angiotensin II on the baroreflex response of the conscious ewe and the conscious fetus. The Journal of Physiology. ,vol. 288, pp. 467- 479 ,(1979) , 10.1113/JPHYSIOL.1979.SP012708
R. Casto, M. I. Phillips, Angiotensin II attenuates baroreflexes at nucleus tractus solitarius of rats American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 250, ,(1986) , 10.1152/AJPREGU.1986.250.2.R193
Carlos M. Ferrario, Mark C. Chappell, E. Ann Tallant, K. Bridget Brosnihan, Debra I. Diz, Counterregulatory Actions of Angiotensin-(1-7) Hypertension. ,vol. 30, pp. 535- 541 ,(1997) , 10.1161/01.HYP.30.3.535
Robson A.S. Santos, Maria J. Campagnole-Santos, Nilo C.V. Baracho, Marco A.P. Fontes, Luciana C.S. Silva, Liomar A.A. Neves, Djenane R. Oliveira, Sordaine M. Caligiorne, Andre R.V. Rodrigues, Carlos Gropen, Wania S. Carvalho, Ana C.Simoes E Silva, Mahesh C. Khosla, Characterization of a new angiotensin antagonist selective for angiotensin-(1–7): Evidence that the actions of angiotensin-(1–7) are mediated by specific angiotensin receptors Brain Research Bulletin. ,vol. 35, pp. 293- 298 ,(1994) , 10.1016/0361-9230(94)90104-X
R Hatton, D Clough, K Faulkner, J Conway, Angiotensin-converting enzyme inhibitor resets baroreceptor reflexes in conscious dogs. Hypertension. ,vol. 3, pp. 676- 681 ,(1981) , 10.1161/01.HYP.3.6.676
EDGAR HABER, THERESA KOERNER, LOT B. PAGE, BERNARD KLIMAN, ANDRE PURNODE, APPLICATION OF A RADIOIMMUNOASSAY FOR ANGIOTENSIN I TO THE PHYSIOLOGIC MEASUREMENTS OF PLASMA RENIN ACTIVITY IN NORMAL HUMAN SUBJECTS. The Journal of Clinical Endocrinology and Metabolism. ,vol. 29, pp. 1349- 1355 ,(1969) , 10.1210/JCEM-29-10-1349
T.A. Kotchen, A.L. Strickland, T.W. Rice, D.R. Walters, A study of the renin-angiotensin system in newborn infants The Journal of Pediatrics. ,vol. 80, pp. 938- 946 ,(1972) , 10.1016/S0022-3476(72)80005-2
Colin I. Johnston, Renin-angiotensin system : a dual tissue and hormonal system for cardiovascular control Journal of Hypertension. ,vol. 10, ,(1992) , 10.1097/00004872-199212000-00002