Suplatast Tosilate affects the Initial Increase in Specific IgE and Interleukin-4 during Immunotherapy for Perennial Allergic Rhinitis
作者： Yushi Washio, Yoshihiro Ohashi, Ayaki Tan
DOI: 10.1080/00016489850182846
关键词:
摘要: Suplatast tosilate can inhibit IL-4 production and suppress IgE synthesis in vitro . However, the theory that agent causes changes of vivo has little experimental support. Immunotherapy could decrease specific response, but such a favourable effect is only possible with prolonged therapy after an initial increase IgE. The use suplatast together immunotherapy may blunt rise serum levels more quickly. Eighty-three adult patients perennial allergic rhinitis due to Dermatophagoides farinae ( D. ) were treated for 6 months one 3 treatments. Seventeen oral administration 300 mg/day alone. Forty-six using standardized Twenty concurrent tosilate. Serum samples wer...
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