Risk factors for survival and local control in chondrosarcoma of bone

作者: K. Ayoub , A. Abudu , F. Fiorenza , A. M. Davies , S. R. Carter

DOI: 10.1302/0301-620X.84B1.11942

关键词:

摘要: We studied 153 patients with non-metastatic chondrosarcoma of bone to determine the risk factors for survival and local tumour control. The minimum follow-up was five years; 52 had axial 101 appendicular tumours. Surgical treatment by amputation in 27 limb-preserving surgery 126. cumulative rate all patients, at 10 15 years, 70% 63%, respectively; 40 developed a recurrence between 3 87 months after 49 metastases. Local associated poor concomitant metastases but not those without. On multivariate analysis independent rates include extracompartmental spread, development high histological grade. Independent inadequate surgical margins size greater than cm. Location within body, type duration symptoms are no prognostic significance. excision an oncologically wide margin provides best prospect both cure control these patients.

参考文章(27)
William F. Enneking, Musculoskeletal tumor surgery ,(1983)
Z. Matějovský, Chemotherapy in complex treatment of bone and soft tissue sarcomas. Oncology. ,vol. 37, pp. 97- 103 ,(1980) , 10.1159/000225505
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
T C Shives, R A McLeod, K K Unni, M F Schray, Chondrosarcoma of the spine. Journal of Bone and Joint Surgery, American Volume. ,vol. 71, pp. 1158- 1165 ,(1989) , 10.2106/00004623-198971080-00006
H J Mankin, J F Connor, A L Schiller, N Perlmutter, A Alho, M McGuire, Grading of bone tumors by analysis of nuclear DNA content using flow cytometry. Journal of Bone and Joint Surgery, American Volume. ,vol. 67, pp. 404- 413 ,(1985) , 10.2106/00004623-198567030-00009
David C. Dahlin, Edward D. Henderson, Chondrosarcoma, A Surgical and Pathological Problem The Journal of Bone & Joint Surgery. ,vol. 38, pp. 1025- 1125 ,(1956) , 10.2106/00004623-195638050-00007
FRANCIS Y. LEE, HENRY J. MANKIN, GERTRUDE FONDREN, MARK C. GEBHARDT, DEMPSEY S. SPRINGFIELD, ANDREW E. ROSENBERG, L. CANDACE JENNINGS, Chondrosarcoma of Bone: An Assessment of Outcome* Journal of Bone and Joint Surgery, American Volume. ,vol. 81, pp. 326- 338 ,(1999) , 10.2106/00004623-199903000-00004
R. J. Grimer, S. R. Carter, R. M. Tillman, D. C. Mangham, A. Abudu, F. Fiorenza, Chondrosarcoma of bone. Journal of Bone and Joint Surgery, American Volume. ,vol. 82, pp. 1203- 1203 ,(2000) , 10.2106/00004623-200008000-00037
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25