MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
作者： Jingwu Duan , Bin Jiang
DOI:
关键词:
摘要: Non-steroidal compounds are provided which useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, have structure formula (I) or an enantiomer, a diastereomer, pharmaceutically acceptable salt, hydrate thereof, where J is selected from NR1 C(R4)(R4a); K NR2 C(R5)(R5a); L NR3 C(R6)(R6a); A, X, Y, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R8, R10, R11, n defined herein. Also pharmaceutical compositions methods diabetes comprising said compounds.
lens.org参考文章(184)
Asa Hedfors, Yi-Lin Li, Johan Malm, Ye Liu, Minsheng Zhang, Charlotta Mellin, Novel thyroid receptor ligands and method ,(1998)
Donald L Fields, Synthesis of a hydroxy group-containing polycyclic aromatic fused ring compound ,(1967)
James Ralph Hanson, Protecting Groups in Organic Synthesis ,(1999)
Scott D. Kuduk, Dai-Shi Su, Wei Han, Bruce D. Dorsey, Mark G. Bock, Michael R. Wood, Benzodiazepine bradykinin antagonists ,(2002)
Bernard Dr. Gilg, Rita Dr. Pitteloud, Bisphenol ester derivatives ,(1996)
Alan M. Warshawsky, Gary A. Flynn, Carboxyalkyl substituted inhibitors of enkephalinase and ACE ,(1992)
Gary Alan Flynn, Alan W. Warshawsky, 2-Substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace ,(1992)
Karnail S. Atwal, Syed Z. Ahmed, Dinos P. Santafianos, Aryl and heterocyclic substituted propenamide derivatives ,(1993)
William N. Washburn, Kathleen M. Poss, Philip M. Sher, Aryloxypropanolamine beta 3 adrenergic agonists ,(1995)
Marion Lanier, Wanlong Jiang, Dragan Marinkovic, Melissa Arellano, Fabio Tucci, Nicole White, Jodie Nelson, Caroline Chen, Joseph Pontillo, Jessica Parker, Chen Chen, Joe Tran, Ligands of melanocortin receptors and compositions and methods related thereto ,(2003)