Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.
作者： Wayne Harshbarger , Chase Miller , Chandler Diedrich , James Sacchettini
DOI: 10.1016/J.STR.2014.11.017
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摘要: … myeloma, and recently carfilzomib was granted US … carfilzomib bound at 2.9 and 2.6 Å, respectively. Our data indicate that the S3 and S4 binding pockets play a pivotal role in carfilzomib…
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