Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits.
作者： Thomas A. Griffin , Dipankar Nandi , Miguel Cruz , Hans Jörg Fehling , Luc Van Kaer
DOI: 10.1084/JEM.187.1.97
关键词: Immunoprecipitation 、 Interferon 、 Biology 、 Protein structure 、 Biogenesis 、 Biochemistry 、 Transfection 、 Interferon gamma 、 Proteasome 、 Major histocompatibility complex
摘要: LMP2, LMP7, and MECL are interferon γ–inducible catalytic subunits of vertebrate 20S proteasomes, which can replace constitutive (delta, X, Z, respectively) during proteasome biogenesis. We demonstrate that requires LMP2 for efficient incorporation into preproteasomes, preproteasomes containing require LMP7 maturation. The latter effect depends on the presequence but not activity. This cooperative mechanism favors assembly homogeneous “immunoproteasomes” all three inducible subunits, suggesting these act in concert to enhance proteasomal generation major histocompatibility complex class I–binding peptides.
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