Cerebrovascular reactivity to carbon dioxide in sepsis syndrome*

摘要: Cerebral dysfunction in sepsis is common critically ill adults. However, little known of the effects on cerebral haemodynamics. We studied 12 sedated and ventilated patients whom had been established for > 24 h. Transcranial Doppler measurements middle artery flow velocity were made at normocapnia, then hypocapnia (-1 kPa) hypercapnia (+1 kPa). From these data, cerebrovascular reactivity to carbon dioxide was calculated. Variables indicating disease severity, systemic cardiovascular status outcome also recorded. found significant changes dioxide. Only three a normal range; seven reduced dioxide, whereas two it raised. In this smaD sample, we could not find any trend association between altered severity illness, or outcome. This study suggests that profoundly affects vascular tone reactivity, only circulation, but vasculature.