Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
作者： Alain Puisieux , Katherine Galvin , Frederic Troalen , Brigitte Bressac , Christophe Marcais
DOI: 10.1096/FASEBJ.7.14.8224613
关键词:
摘要: We analyzed the status of retinoblastoma and p53 genes in 10 human hepatoma cell lines. Polyclonal anti-peptide antibodies generated against peptides homologous to COOH-terminal leucine-zipper domains protein allowed us identify two lines (Hep 3B FOCUS) with abnormal expression. The same have both lacked In contrast gene, expression gene was six additional Indeed, only Hep G2 hepatoblastoma line (and its derivative G2/2215) appeared normal Our studies indicate that abnormalities are common but aberrations rare
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