Efficacy of sarolaner (Simparic™) against induced infestations of Amblyomma cajennense on dogs.

摘要: Amblyomma cajennense is the main vector of Rickettsia rickettsii which causes Brazilian spotted fever. This adult tick preferably infests horses and capybaras, but has low host specificity during its immature stages, thus posing a threat to humans dogs. In this study, efficacy sarolaner (Simparic™/Simparica®, Zoetis) when administered once orally dogs at 2 mg/kg was evaluated against induced infestations A. nymphs for up 35 days after treatment. Based on pretreatment counts, 20 were randomly allocated treatment with (Simparic™) dosed body weight or placebo Day 0 study. Artificial performed using laboratory raised study days -2, 5, 12, 19, 26 33. Efficacy determined 48 h post-treatment post-infestation each time point relative counts that received placebo. There no adverse reactions A single dose provided 100% 2, 7 14; ≥ 99.6% 21, 28 35. Geometric mean live significantly lower than those all (P < 0.0001). Under conditions present existing within weekly challenges least