Hierarchical micro/nanostructured titanium with balanced actions to bacterial and mammalian cells for dental implants.

摘要: A versatile strategy to endow dental implants with long-term antibacterial ability without compromising the cytocompatibility is highly desirable combat implant-related infection. Silver nanoparticles (Ag NPs) have been utilized as a effective and broad-spectrum agent for surface modification of biomedical devices. However, high mobility subsequent hazardous effects particles on mammalian cells may limit its practical applications. Thus, Ag NPs were immobilized sand-blasted, large grit, acid-etched (SLA) titanium by manipulating atomic-scale heating effect silver plasma immersion ion implantation. The implantation-treated SLA gave rise both good activity excellent compatibility cells. rendered was assessed using Fusobacterium nucleatum Staphylococcus aureus, commonly suspected pathogens peri-implant disease. offered defense against multiple cycles bacteria attack in F. S. mechanism independent release. showed higher susceptibility than which might be explained presence different wall structures. Moreover, had no apparent toxic influence viability, proliferation, differentiation rat bone marrow mesenchymal stem These results demonstrated that bactericidal could obtained very small quantities NPs, not detrimental involved osseointegration process, promising titanium-based commercial surfaces.