Relaxant effects of sodium nitroprusside and NONOates in goat middle cerebral artery: delayed impairment by global ischemia-reperfusion.

摘要: Global cerebral ischemia and subsequent reperfusion induce early impairment of the vasodilator responses to hypercapnia vasoactive substances. Nitric oxide (NO) is involved in regulation blood flow (CBF) both health disease. The present study was designed assess possible changes cerebrovascular reactivity NO donors induced by ischemia-reperfusion goats. Female goats (n = 9) were subjected 20 min global under halothane/N2O anesthesia. Sixteen additional sham-operated as a control group. One week later effects on relaxations sodium nitroprusside (SNP), diethylamine/NO (DEA/NO), diethylenetriamine/NO (DETA/NO), spermine/NO (SPER/NO) studied rings middle artery (MCA) isolated an organ bath for isometric tension recording. SNP, DEA/NO, DETA/NO, SPER/NO concentration-dependent MCA precontracted with KCl (DEA/NO > SNP DETA/NO) or endothelin-1 DETA/NO). Relaxations always higher endothelin-1-precontracted arteries. after concentration-response curves DEA/NO displaced right, indicating reduction relaxant potency donors. classical nitrovasodilator NONOates relaxation goat which partially inhibited arterial depolarization. followed induces delayed smooth muscle, results reduced vasodilatory large