Effects of CAS 754, a new nitric oxide donor, on regional cerebral blood flow in focal cerebral ischemia

摘要: Nitric oxide (NO) plays an important role in regulating regional cerebral blood flow (rCBF).This study was performed to compare the effects of NO donor, CAS 754, a sydnonimine derivative, and sodium nitroprusside (SNP) on rCBF ischemic nonischemic brain regions. Twenty-eight rats were anesthetized with 1.4% isoflurane mechanically ventilated. A middle artery (MCA) occluded each animal. In 754 group (n = 7), 40 min after MCA occlusion, 4-6 mg/kg administered intravenously (IV) decrease mean arterial pressure (MAP) 55-60 mm Hg. SNP infusion started MAP same level as that group. CAS-Ph phenylephrine infused had been order maintain at control (95-100 Hg). The remaining seven used measured using14 C-iodoantipyrine all four groups animals 1 h occlusion (20 start drug administration). average regions (121 +/- 15 mL centered dot (-1) 100 g-1) increased by 34% (162 39 min-1 g-1). However, did not significantly change (114 5 Neither nor affected cortex (control 51 7, 61 13, 53 18 Phenylephrine 754-treated affect or conclusion, our demonstrated more effective vasodilator than when systemically. cortex, neither improved rCBF. Failure improve does appear be due hypotension induced 754. (Anesth Analg 1995;80:703-8)