Selective opening of the blood-tumor barrier by a nitric oxide donor and long-term survival in rats with C6 gliomas.
作者： Astrid Weyerbrock , Stuart Walbridge , Ryszard M. Pluta , Joseph E. Saavedra , Larry K. Keefer
DOI: 10.3171/JNS.2003.99.4.0728
关键词: Blood–brain barrier 、 Immunology 、 Medicine 、 Hemodynamics 、 Sodium nitrite 、 Glioma 、 Nitric oxide 、 Internal carotid artery 、 Permeability (electromagnetism) 、 Pharmacology 、 Vascular permeability
摘要: Object. The response of brain tumors to systemic chemotherapy is limited by the blood—tumor barrier (BTB). Nitric oxide (NO) has been implicated in regulation vascular permeability and blood flow. authors evaluated effects exogenous NO, which was released from a short-acting NO donor (Proli/NO), those metabolites on capillary normal tissue using quantitative autoradiography C6 glioma model rats. Methods. Proli/NO infused at wide dose range (10−2 10−12 M) either intravenously or into internal carotid artery (ICA) demonstrated substantial tumor-selective increases blood-brain (BBB) various-sized tracers ([14C]aminoisobutyric acid, [14C]sucrose, [14C]dextran). Internal intravenous administration sodium nitrite had comparable effect BTB permeability. microvascular could be obtained without causing hemodynamic side effect...
sci-hub.se 参考文章(47)
K. Schallock, H. C. Ludwig, I. Feiz-Erfan, V. Bockermann, J. Behnke-Mursch, E. Markakis, Expression of nitric oxide synthase isozymes (NOS I-III) by immunohistochemistry and DNA in situ hybridization. Correlation with macrophage presence, vascular endothelial growth factor (VEGF) and oedema volumetric data in 220 glioblastomas. Anticancer Research. ,vol. 20, pp. 299- 304 ,(2000)
Koichiro Matsukado, Keith L. Black, Shin Nakano, Increased Brain Tumor Microvessel Permeability after Intracarotid Bradykinin Infusion Is Mediated by Nitric Oxide Cancer Research. ,vol. 56, pp. 4027- 4031 ,(1996)
D. Fukumura, F. Yuan, R. K. Jain, M. Endo, Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions. American Journal of Pathology. ,vol. 150, pp. 713- 725 ,(1997)
Hiroshi Maeda, Takaaki Akaike, Masaki Yoshida, Moritaka Suga, Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger. Journal of Leukocyte Biology. ,vol. 56, pp. 588- 592 ,(1994) , 10.1002/JLB.56.5.588
Louis J. Ignarro, Endothelium-derived nitric oxide: actions and properties. The FASEB Journal. ,vol. 3, pp. 31- 36 ,(1989) , 10.1096/FASEBJ.3.1.2642868
Kenneth D. Aldape, Jay E. Brenman, David S. Bredt, Mark A. Israel, Charles S. Cobbs, Expression of nitric oxide synthase in human central nervous system tumors. Cancer Research. ,vol. 55, pp. 727- 730 ,(1995)
R M Palmer, S Moncada, E A Higgs, NITRIC OXIDE: PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY Pharmacological Reviews. ,vol. 43, pp. 109- 142 ,(1991)
Raymond T. Bartus, Pamela Snodgrass, Joanne Marsh, Mary Agostino, Alexis Perkins, Dwaine F. Emerich, Intravenous Cereport (RMP-7) Modifies Topographic Uptake Profile of Carboplatin within Rat Glioma and Brain surrounding Tumor, Elevates Platinum Levels, and Enhances Survival Journal of Pharmacology and Experimental Therapeutics. ,vol. 293, pp. 903- 911 ,(2000)
D F Emerich, P Snodgrass, R Dean, M Agostino, B Hasler, M Pink, H Xiong, B S Kim, R T Bartus, Enhanced delivery of carboplatin into brain tumours with intravenous Cereport (RMP-7): dramatic differences and insight gained from dosing parameters. British Journal of Cancer. ,vol. 80, pp. 964- 970 ,(1999) , 10.1038/SJ.BJC.6690450
Oak Z. Chi, Hwu M. Wei, Harvey R. Weiss, Effects of CAS 754, a new nitric oxide donor, on regional cerebral blood flow in focal cerebral ischemia Anesthesia & Analgesia. ,vol. 80, pp. 703- 708 ,(1995) , 10.1097/00000539-199504000-00009