Endothelial Activation Markers in Sub-clinical Atherosclerosis: Insights from Mechanism-Based Paradigms
作者： Victoria L. M. Herrera , Joseph A. Vita
DOI: 10.1007/978-1-60327-179-0_13
关键词:
摘要: Endothelial cell (EC) activation mediates inflammation and involves several effectors such as E-selectin, P-selectin, ICAM-1, VCAM-1. These EC markers are detected to be significantly increased in clinical coronary artery disease (CAD), mildly subclinical CAD compared with non-disease reference groups. Because is implicated all stages of thought underlie plaque destabilization rupture, monitoring the increase could a surrogate endpoint (subCAD) progression, and/or response prevention/intervention strategies. While progression complex, requires contemporaneous analysis multi-pathway markers, provide insight into subCAD especially when levels approach those acute syndromes (ACS). Clearly, mechanism-based deductions compelling evidence that should integrated management subCAD; however, much study remains done.
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sci-hub.st 参考文章(61)
Christopher Heeschen, Stefanie Dimmeler, Christian W Hamm, Stephan Fichtlscherer, Maarten L Simoons, Andreas M Zeiher, CAPTURE Study Investigators, Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. Journal of the American College of Cardiology. ,vol. 45, pp. 229- 237 ,(2005) , 10.1016/J.JACC.2004.09.060
Ron Waksman, Johannes Schaar, Patrick W. Serruys, The Vulnerable Plaque Informa Healthcare. ,(2007)
Douglas B. Cines, Rodger P. McEver, Joseph Loscalzo, Jordan S. Pober, Guy A. Zimmerman, Eleanor S. Pollak, Ann Marie Schmidt, Keith R. McCrae, David M. Stern, Barbara A. Konkle, Elliot S. Barnathan, Bradford S. Schwartz, Timothy M. Wick, Clayton A. Buck, Bruce A. Hug, Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders Blood. ,vol. 91, pp. 3527- 3561 ,(1998) , 10.1182/BLOOD.V91.10.3527
J. J. Neefjes, T. Cinek, M. A. Shaffer, T. J. Ahern, T. M. A. A. Jeunhomme, E. F. Smeets, J. F. M. Leeuwenberg, W. A. Buurman, E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology. ,vol. 77, pp. 543- 549 ,(1992)
D O Haskard, R R Johnson-Tidey, J R Coucher, N P Gall, R N Poston, Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. American Journal of Pathology. ,vol. 140, pp. 665- 673 ,(1992)
Crawford Parker Iii, Joseph A Vita, Jane E Freedman, Soluble adhesion molecules and unstable coronary artery disease Atherosclerosis. ,vol. 156, pp. 417- 424 ,(2001) , 10.1016/S0021-9150(00)00672-9
Andrew J.H. Gearing, Walter Newman, Circulating adhesion molecules in disease. Immunology Today. ,vol. 14, pp. 506- 512 ,(1993) , 10.1016/0167-5699(93)90267-O
Hasan Turhan, Ali Riza Erbay, Ayse Saatci Yasar, Yuksel Aksoy, Asuman Bicer, Gulay Yetkin, Ertan Yetkin, Plasma soluble adhesion molecules; intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin levels in patients with isolated coronary artery ectasia. Coronary Artery Disease. ,vol. 16, pp. 45- 50 ,(2005) , 10.1097/00019501-200502000-00009
Shih-Jen Hwang, Christie M. Ballantyne, A. Richey Sharrett, Louis C. Smith, Clarence E. Davis, Antonio M. Gotto, Eric Boerwinkle, Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: The Atherosclerosis Risk In Communities (ARIC) study Circulation. ,vol. 96, pp. 4219- 4225 ,(1997) , 10.1161/01.CIR.96.12.4219
Lori Mosca, C-Reactive Protein — To Screen or Not to Screen? New England Journal of Medicine. ,vol. 347, pp. 1615- 1617 ,(2002) , 10.1056/NEJME020127