Development of novel rosuvastatin nanostructured lipid carriers for oral delivery in an animal model
作者： Jun Li , Min Yang , Wenrong Xu
DOI: 10.2147/DDDT.S169522
关键词:
摘要: Objective The aim of this study was to prepare rosuvastatin nanostructured lipid carriers (RST-NLCs) in order increase the bioavailability RST. Materials and methods RST-NLCs were prepared by hot melt high-pressure homogenization method. physicochemical parameters characterized terms particle size, zeta potential, morphology, entrapment efficiency, vitro release behavior. Results mean size found be 98.4±0.3 nm. efficiency 84.3%±1.3%. RST slowly released from NLCs over a period 48 h PBS. A similar phenomenon also observed pharmacokinetic rats, which area under curve 1.65-fold higher than that tablet powder. Conclusion results pharmacodynamics showed effective lipid-lowering activity could explained fact resulted sustained RST, have increased absorption provided bioavailability.
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