Transit of solids through the human colon : regional quantification in the unprepared bowel

摘要: We used a noninvasive method to label the solid phase of contents in unprepared human colon. 111In-labeled Amberlite pellets (0.5-1.8 mm diam) were placed gelatin capsule that was then coated with pH-sensitive polymer (methacrylate). In vitro, capsules disintegrated simulated small bowel within 1-2 h; when ingested by healthy subjects, released radiolabel distal ileum or proximal colon 13 15 subjects. Transit 111In-pellets through could be quantitated radioscintigraphically. Segmental transit defined ascending (AC), transverse (TC), descending (DC), and rectosigmoid (RS) Radioactivity also stools. At 12 h, radioactivity most obvious AC (59 +/- 11%, mean SE) TC (21 6%); at 24 counts distributed equally between AC, TC, stools (P greater than 0.05); 48 56 11% had been excreted, although 30 10% remained TC. amount DC RS lower less 0.05) Emptying characterized an initial lag period, no emptied into followed period emptying approximately linear. Thus this simple approach is able The appear sites storage residue, whereas left function mainly as conduits.