Antibodies to MOG in adults with inflammatory demyelinating disease of the CNS.

摘要: Objective: To evaluate the clinical relevance of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in a cohort adults with inflammatory demyelinating disease (IDD) CNS. Methods: Live cell-based assays for MOG-Ab (IgG1 subset) and to aquaporin-4 (AQP4-Ab) were performed 270 adult patients IDD 72 controls. Patients first grouped by positive result as or AQP4-Ab, remainder published diagnostic criteria. Results: Seventeen (6.3%) had MOG-Abs 49 (18.1%) AQP4-Abs; none both antibodies. The predominantly manifested isolated symptoms optic neuritis (83%). One-third these experienced relapses, which involved only nerve, all relapsed within 1 year onset. At onset, MRI group uniquely demonstrated perineural enhancement, extending soft tissues around nerves (33%). Although about 30% brain lesions, they fewer periventricular lesions than 26 relapsing-remitting multiple sclerosis (MS); ovoid perpendicular ventricle. Moreover, did not meet criteria definite neuromyelitis optica (NMO) less spinal cord involvement AQP4-Ab group. Four (23.5%) poor visual outcomes ( Conclusions: may be disease-specific biomarker who have distinct from NMO MS. radiologic well manifestations can useful their differential diagnosis.