Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes
作者： Peter S Lacy , David G O'Brien , Adrian G Stanley , Mairead M Dewar , Philip PR Swales
DOI: 10.1097/00004872-200410000-00016
关键词:
摘要: Objective Increased arterial stiffness is a risk factor for cardiovascular disease and feature associated with diabetes. Pulse wave velocity (PWV) an accepted index of augmentation (Al) derived from radial applanation tonometry has been advocated as measurement stiffness. This study compares the relationship between PWV Al in people without Design methods A total 66 diabetes age-matched non-diabetic controls were studied. Central aortic pressure waves generated using over artery used to calculate Al. Carotid-femoral (PWV cf ) was measured simultaneously. Results Relative controls, increased pulse (PP) (P<0.01). In contrast, did not differ groups even after adjustment heart rate. observation remained consistent irrespective type, site, presence or absence antihypertensive therapy. Multiple regression analysis revealed be significant determinant , but Conclusions PP are diabetes, this These findings conclusively demonstrate that reliable measure
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sci-hub.se 参考文章(72)
J. H. B. Scarpello, T. R. P. Martin, J. D. Ward, Ultrasound measurements of pulse-wave velocity in the peripheral arteries of diabetic subjects. Clinical Science. ,vol. 58, pp. 53- 57 ,(1980) , 10.1042/CS0580053
MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. The Lancet. ,vol. 361, pp. 2005- 2016 ,(2003) , 10.1016/S0140-6736(03)13636-7
Christoph D Gatzka, James D Cameron, Anthony M Dart, Karen L Berry, Bronwyn A Kingwell, Elizabeth M Dewar, Chris M Reid, Garry LR Jennings, Correction of carotid augmentation index for heart rate in elderly essential hypertensives American Journal of Hypertension. ,vol. 14, pp. 573- 577 ,(2001) , 10.1016/S0895-7061(00)01320-0
Jacques Blacher, Michel E. Safar, Alain P. Guerin, Bruno Pannier, Sylvain J. Marchais, Gérard M. London, Aortic pulse wave velocity index and mortality in end-stage renal disease Kidney International. ,vol. 63, pp. 1852- 1860 ,(2003) , 10.1046/J.1523-1755.2003.00932.X
Christopher S Hayward, Raymond P Kelly, Gender-related differences in the central arterial pressure waveform Journal of the American College of Cardiology. ,vol. 30, pp. 1863- 1871 ,(1997) , 10.1016/S0735-1097(97)00378-1
Jukka Westerbacka, Antti Uosukainen, Sari Mäkimattila, Anna Schlenzka, Hannele Yki-Järvinen, Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus. Hypertension. ,vol. 35, pp. 1043- 1048 ,(2000) , 10.1161/01.HYP.35.5.1043
Jukka Westerbacka, Anneli Seppälä-Lindroos, Hannele Yki-Järvinen, Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome. The Journal of Clinical Endocrinology and Metabolism. ,vol. 86, pp. 5262- 5268 ,(2001) , 10.1210/JCEM.86.11.8047
Robert A. J. M. van DIJK, Frans J. van ITTERSUM, Nico WESTERHOF, Els M. van DONGEN, Otto KAMP, Coen D. A. STEHOUWER, Determinants of brachial artery mean 24 h pulse pressure in individuals with Type II diabetes mellitus and untreated mild hypertension. Clinical Science. ,vol. 102, pp. 177- 186 ,(2002) , 10.1042/CS20010135
Jukka Westerbacka, Ian Wilkinson, John Cockcroft, Tapio Utriainen, Satu Vehkavaara, Hannele Yki-Järvinen, Diminished wave reflection in the aorta. A novel physiological action of insulin on large blood vessels. Hypertension. ,vol. 33, pp. 1118- 1122 ,(1999) , 10.1161/01.HYP.33.5.1118
R Kelly, C Hayward, A Avolio, M O'Rourke, Noninvasive determination of age-related changes in the human arterial pulse. Circulation. ,vol. 80, pp. 1652- 1659 ,(1989) , 10.1161/01.CIR.80.6.1652