Hyaluronidase additional to standard chemotherapy improves outcome for children with malignant brain tumors

摘要: Ex vivo experiments with vital brain tumor samples show that hyaluronidase enhances the permeation of carboplatin into tissue a matrix rich in hyaluronic acid. We achieved long-lasting second remissions for children relapsed malignant tumors treated carboplatin, etoposide and this enzyme. Thereafter, we initiated pilot study where added to first line standard therapy prevent deadly relapses right from beginning. All 19 patients admitted our pediatric neurooncological center 1992 1994 were included study. Kaplan-Meier estimation event-free survival overall after 3 years follow-up indicates significantly better outcome hyaluronidase-treated group. The receiving supportive suffered less (P = 0.034) had chance 0.045) compared historical control 21 same regimen but without (product limit analysis log-rank test, P together primary treatment seemed gain most benefit.