Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.

摘要: Cells in vivo reside within complex microenvironments composed of both biochemical and biophysical cues. The dynamic feedback between cells their hinges upon cues that regulate critical cellular behaviors. Understanding this regulation from sensing to reaction is therefore critical, a large effort afoot identify mathematically model the fundamental mechanobiological mechanisms underlying regulation. This review provides perspective on recent progress mathematical models for responses microenvironments, including strain, osmotic shock, fluid shear stress, mechanical force, matrix rigidity, porosity, shape. highlights key successes failings existing models, discusses future opportunities challenges field.