Regulatory Effects of Neuroinflammatory Responses Through Brain-Derived Neurotrophic Factor Signaling in Microglial Cells
作者： Sheng-Wei Lai , Jia-Hong Chen , Hsiao-Yun Lin , Yu-Shu Liu , Cheng-Fang Tsai
DOI: 10.1007/S12035-018-0933-Z
关键词:
摘要: Inhibition of microglial over-activation is an important strategy to counter balance neurodegenerative progression. We previously demonstrated that the adenosine monophosphate-activated protein kinase (AMPK) may be a therapeutic target in mediating anti-neuroinflammatory responses microglia. Brain-derived neurotrophic factor (BDNF) one major factors produced by astrocytes maintain development and survival neurons brain, have recently been shown modulate homeostasis neuroinflammation. Therefore, present study focused on BDNF-mediated neuroinflammatory provide endogenous regulation Among tested neuroinflammation, epigallocatechin gallate (EGCG) minocycline exerted BDNF upregulation inhibit COX-2 proinflammatory mediator expressions. Furthermore, both EGCG upregulated expression microglia through AMPK signaling. In addition, also increased expressions erythropoietin (EPO) sonic hedgehog (Shh). modulation astrocyte-conditioned medium (AgCM) decreased The anti-inflammatory effects were mediated EPO/Shh Our results indicated BDNF-EPO-Shh novel-signaling pathway underlies inflammatory regarded as potential diseases. This reveals better understanding crosstalk between regulate actions, which could novel for treatment neuroinflammation
springer.com
sci-hub.se 参考文章(94)
E.M. Torres, C. Monville, P.R. Lowenstein, M.G. Castro, S.B. Dunnett, Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age. Brain Research Bulletin. ,vol. 68, pp. 31- 41 ,(2005) , 10.1016/J.BRAINRESBULL.2005.08.021
Andrew P McMahon, Philip W Ingham, Clifford J Tabin, Developmental roles and clinical significance of hedgehog signaling. Current Topics in Developmental Biology. ,vol. 53, pp. 1- 114 ,(2003) , 10.1016/S0070-2153(03)53002-2
Kenneth L. Pitter, Ilaria Tamagno, Xi Feng, Kaushik Ghosal, Nduka Amankulor, Eric C. Holland, Dolores Hambardzumyan, The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions. Glia. ,vol. 62, pp. 1595- 1607 ,(2014) , 10.1002/GLIA.22702
Rodney Ritzel, Louise D McCullough, Fudong Liu, Anita R Patel, Microglia and ischemic stroke: a double-edged sword. International journal of physiology, pathophysiology and pharmacology. ,vol. 5, pp. 73- 90 ,(2013)
Barbara Viviani, Stefano Bartesaghi, Emanuela Corsini, Pia Villa, Pietro Ghezzi, Angela Garau, Corrado L. Galli, Marina Marinovich, Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor. Journal of Neurochemistry. ,vol. 93, pp. 412- 421 ,(2005) , 10.1111/J.1471-4159.2005.03033.X
Tarek A. Samad, Kimberly A. Moore, Adam Sapirstein, Sara Billet, Andrew Allchorne, Stephen Poole, Joseph V. Bonventre, Clifford J. Woolf, Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity Nature. ,vol. 410, pp. 471- 475 ,(2001) , 10.1038/35068566
Zhongwu Liu, Michael Chopp, Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke Progress in Neurobiology. ,vol. 144, pp. 103- 120 ,(2016) , 10.1016/J.PNEUROBIO.2015.09.008
Fabio Fumagalli, Raffaella Molteni, Francesca Calabrese, Paola Francesca Maj, Giorgio Racagni, Marco Andrea Riva, Neurotrophic Factors in Neurodegenerative Disorders : Potential for Therapy CNS Drugs. ,vol. 22, pp. 1005- 1019 ,(2008) , 10.2165/0023210-200822120-00004
Jeffery A Porter, Stephen C Ekker, Woo-Jin Park, Doris P von Kessler, Keith E Young, Chien-Huan Chen, Yong Ma, Amina S Woods, Robert J Cotter, Eugene V Koonin, Philip A Beachy, Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell. ,vol. 86, pp. 21- 34 ,(1996) , 10.1016/S0092-8674(00)80074-4
Sepill Park, Keum Sil Lee, Young Jae Lee, Hyun Ah Shin, Hwang Yoon Cho, Kyu Chang Wang, Yong Sik Kim, Hoon Taek Lee, Kil Saeng Chung, Eun Young Kim, Jinho Lim, Generation of dopaminergic neurons in vitro from human embryonic stem cells treated with neurotrophic factors Neuroscience Letters. ,vol. 359, pp. 99- 103 ,(2004) , 10.1016/J.NEULET.2004.01.073