Non-human viruses developed as therapeutic agent for use in humans

摘要: Viruses usually infect a restricted set of host species, and only in rare cases does productive infection occur outside the natural range. Infection new species can manifest as distinct disease. In this respect, use non-human viruses clinical therapy may be cause for concern. It could provide opportunity to adapt transferred recipient's relatives or medical caretakers, even normal species. Such environmental impact is evidently undesirable. To forecast future viruses, literature study was performed identify that are being considered application therapeutic agents humans. Twenty-seven virus were identified (pre)clinical development, mainly oncolytic agents. For risk management, it essential potential consequences assessed before initiating use, if not formally classified genetically modified organism. aid such assessment, each these one five relative categories, ranging from "Negligible" "Very High". Canary pox Autographa californica baculovirus assigned classification, Seneca Valley virus, murine leukemia Maraba "High" category. A complicating factor classification scarcity publicly available information on key aspects biology some score increased precaution.