FDG-PET metabolic response predicts outcomes in anal cancer managed with chemoradiotherapy
作者： F L Day , E Link , S Ngan , T Leong , K Moodie
DOI: 10.1038/BJC.2011.274
关键词:
摘要: The aim was to investigate the correlation between 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) metabolic response chemoradiotherapy and clinical outcomes in squamous cell carcinoma (SCC) of anus. A total 48 patients with biopsy-proven anal SCC underwent FDG-PET scans at baseline post (54 Gy, concurrent 5-FU/mitomycin). Kaplan–Meier analysis used determine survival according response. In all, 79% (n=38) had a complete (CMR) all sites disease, 15% (n=7) CMR regional nodes but only partial primary tumour (overall (PMR)) 6% (n=3) progressive distant disease despite locoregionally no (NR)). 2-year progression-free (PFS) 95% for CMR, 71% PMR 0% NR (P<0.0001). 5-year overall (OS) 88% 69% Cox proportional hazards regression analyses PFS OS found significant associations incomplete (PMR+NR) vs treatment only, (HR 4.1 (95% CI: 1.5–11.5, P=0.013) 6.7 2.1–21.6, P=0.002), respectively). cancer is significantly associated OS, this cohort stronger predictor than T or N stage.
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