fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster.

摘要: A number of fundamental processes comprise the cell division cycle, including spindle formation, chromosome segregation, and cytokinesis. Our current understanding these has benefited from isolation analysis mutants, with meiotic divisions in male germline Drosophila being particularly well suited to identification required genes. We show here that fumble (fbl) gene is for Drosophila. find dividing cells fbl-deficient testes exhibit abnormalities bipolar organization, contractile ring formation. Cytological larval neuroblasts null mutants reveals a reduced mitotic index presence polyploid cells. Molecular demonstrates fbl encodes three protein isoforms, all which contain domain high similarity pantothenate kinases A. nidulans mouse. The largest Fumble isoform dispersed cytoplasm during interphase, concentrates around at metaphase, localizes midbody telophase. During early embryonic development, areas membrane deposition and/or rearrangement, such as metaphase cellularization furrows. Given role kinase production Coenzyme phospholipid biosynthesis, this pattern localization suggestive synthesis. propose synthesis redistribution membranous structures cycle underlie defects mutant