Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics
作者： Shivangi Gupta
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摘要: Chronic Lymphocytic Leukaemia, CLL, is one of the most common forms of leukaemia in elderly. The treatment regimen determines outcome patients with CLL and the efficiency this treatment modulated by concentration of cancer treating drugs cancer cells. Uptake transporters the SLC (solute carrier) family can help overcome chemoresistance by the application transporter-specific cytostatics. In present study, we investigated expression SLC six lymphoma cell lines patient samples. Five six cell tested, as well samples from patients demonstrated a higher SLC22A1 (OCT1) than healthy lymphocytes. uptake organic cation [3H]MPP into OCT1 stably transfected CHO cells was significantly inhibited by irinotecan, mitoxantrone paclitaxel. Ki values as determined using Dixon plot analyses were 1.71
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