REGULATION OF THE IMMUNE RESPONSE I. REDUCTION IN ABILITY OF SPECIFIC ANTIBODY TO INHIBIT LONG-LASTING IGG IMMUNOLOGICAL PRIMING AFTER REMOVAL OF THE FC FRAGMENT

摘要: The ability of 7S and F(ab')2 antibody fragments to suppress priming with low doses antigen was compared. preparation approximately 100–1000 times more potent than the when agglutinin titers two preparations were same. presence any in may reflect an inherent capacity or contamination small amounts antibody. difference between is attributed lack Fc portion on be needed prevent rapid excretion from body, induce phagocytosis antigen-antibody complexes consequent breakdown elimination antigen, inactivate antigen-sensitive cells reacting antigenic determinants. More detailed studies will permit a better assessment importance these three possible regulatory roles immunoglobulin immune response.