Identification of Candida dubliniensis in a study of HIV-seropositive pediatric dental patients.

摘要: Purpose: The combination of an immature immune system and suppressed cellular immunity in children with HIV infections provides optimal conditions for rapid disease progression. As a result, pediatric AIDS has become major epidemiological challenge. Oral fungal colonization remains one the most common opportunistic observed both adult infected patients. Although Candida albicans is frequently isolated species, recently characterized C. dubliniensis, gained considerable attention due to its almost exclusive association HIV-seropositive individuals. purpose this study was prospectively screen presence dubliniensis among HIV+ Methods: samples taken from twenty-seven were cultured yeast. All positive yeast isolates obtained screened by use tests germ tube chlamydospore production, detection inability grow at 45°C, colony color on CHROMagar medium, coaggregation Fusobacterium nucleatum ATCC 49256 results sugar assimilation testing API 20C AUX identification system. Results: Among 27 patients tested, 3 found harbor which also grew glabrata; 12 colonized albicans, while remaining negative Identification three genetically confirmed electrophoretic karyotyping. be susceptible fluconazole (MIC≤0.25ug/ml). Conclusions: These confirm novel species dental seropositive population support need further investigation into prevalence pathogenesis dubliniensis. (Pediatr Dent 22:234-238, 2000)