Mapping of genetic factors influencing the weight of cystic fibrosis knockout mice.

摘要: One of the poorly understood clinical manifestations cystic fibrosis (CF) is low body weight. Mice in which CF causative gene, transmembrane conductance regulator (Cftr), has been knocked out reflect this as they are smaller than age-matched littermates. The variable weight F2 Cftr ?/? mice derived from a cross between congenic C57BL/6J and BALB/cJ heterozygotic permits mapping modifiers phenotype. In report, quantitative trait loci (QTL) was used to identify chromosomal locations genes that contribute 12-week-old mice. Five were detected with four five acting sex-specific manner. Significant linkage phenotype region Chromosome (Chr) 13 D13Mit179 D13Mit254 (LOD = 4.2) established female mice; suggestive on Chrs 7 10 identified. weights male suggestively linked regions 1 6, same locus Chr did not influence limited set control thus presumed be specific their effects. Further study these putative may provide insight pathogenesis fibrosis.