Psychiatric comorbidities in temporal lobe epilepsy: Possible relationships between psychotic disorders and involvement of limbic circuits

摘要: Objective: Mounting evidence suggests that the limbic system is pathologically involved in cases of psychiatric comorbidities temporal lobe epilepsy (TLE) patients. Our objective was to develop a conceptual framework describing how neuropathological and connectivity changes might contribute development psychosis potential neurobiological mechanisms cause schizophrenia-like TLE Methods: In this review, clinical findings, especially brain circuitry system, were examined together enhance our understanding association between psychosis. Finally, importance animal models disorders discussed. Conclusions: symptoms coexist more frequently than chance would predict. Damage deregulation among critical anatomical regions, such as hippocampus, amygdala, thalamus, temporal, frontal cingulate cortices, predispose brains Studies effects kindling injection neuroactive substances on behavior electrophysiological patterns may offer model seizures humans increase vulnerability patients symptoms.