Hypertension in late adolescence and cardiovascular mortality in midlife: a cohort study of 2.3 million 16- to 19-year-old examinees

摘要: The effect of early hypertension on midlife cardiovascular (CV) mortality remains controversial. We assessed the association established in late adolescence with subsequent CV mortality. Of 2,298,130 Israeli adolescents (60 % males; age 17.4 ± 0.3 years) who underwent a compulsory medical examination prior to military service between 1967 and 2010, 8720 teenagers (0.4 %) were formally diagnosed persistent hypertension. Using Cox proportional hazards modeling, we compared hypertensive group large normotensive regard time event analysis due cerebrovascular accidents (CVA), coronary heart disease (CHD), sudden death (SD) their summation as (CVD). During 45,729,521 person-years follow-up, identified 2918 deaths—2879 39 among 2,289,410 adolescents, respectively. Hypertension at young was associated threefold elevation stroke normotension when adjusted for sex, examination, birth year, country origin, socioeconomic status, education, body mass index (BMI) height [hazard ratio (HR) 3.12; 95 % confidence interval (CI) 1.76–5.54; p < 0.001]. There no significant CHD or SD. An increased risk overall CVD youngsters (HR 1.51; 95 % CI 1.10–2.07) attenuated after adjusting BMI other covariates 1.24; 0.90–1.72). Established independently elevated midlife. This finding warrants confirmatory large-scale long-term follow-up studies address distant effects adolescent