Dacryoendoscopic observation and incidence of canalicular obstruction/stenosis associated with S-1, an oral anticancer drug

摘要: To report dacryoendoscopic observations and the incidence of lacrimal obstruction/stenosis associated with S-1, an oral anticancer drug. Retrospective, nonrandomized clinical trial. A total 52 patients (41 men, 11 women; age 42–93 years) who were prescribed drug S-1 studied. Patients suffered eye complaints following treatment underwent ophthalmic examination, probing irrigation. whose tear meniscus was high or had abnormal irrigation evaluated by dacryoendoscopy. Overall, 5 S-1-treated (9.6%) experienced passage stenosis/obstruction. One patient punctal stenosis, four canalicular obstruction/stenosis. The onset epiphora ranged from 2 to 8 months (4.4 ± 2.2 months, mean ± SD) after initiation chemotherapy. receiving should be for potential disorders, particularly Dacryoendoscopic observation is effective diagnosis this side effect.