Lacrimal canalicular stenosis associated with systemic 5‐fluorouracil therapy

摘要: . Purpose: Ocular side effects of systemic 5-fluorouracil therapy include excessive lacrimation which often resolves on cessation therapy. Permanent stenosis lacrimal puncta and canaliculi is rare. This report highlights this uncommon complication therapy. Methods: Report two cases review literature. Results: Severe may be associated with prolonged therapy. Conclusion: It important for both the oncologist ophthalmologist to aware potential ocular toxicity 5-fluorouracil. Surgical management relieve epiphora challenging, early intervention beneficial.