THE LOSS OF CIRCADIAN RHYTHM FOR INTACT PARATHYROID HORMONE AND NEPHROGENOUS CYCLIC AMP IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM
作者： F. C. LOGUE , W. D. FRASER , S. J. GALLACHER , D. A. CAMERON , D. St J. O'REILLY
DOI: 10.1111/J.1365-2265.1990.TB00888.X
关键词:
摘要: SUMMARY The measurement of serum intact parathyroid hormone (PTH) (1-84) over a 24-h period has shown the existence circadian rhythm in normal males which is absent patients with primary hyperparathyroidism. The physiological significance this observation reflected presence parallel changes nephrogenous cyclic adenosine monophosphate (N-cAMP) normals are also Serum calcium, adjusted for variations albumin concentrations, showed transient fall subjects prior to nocturnal rise PTH (1-84). A similar calcium was observed hyperparathyroid patients. phosphate subjects, and an attenuated persisted These data suggest that both ionic factors higher centres play important roles fine control secretion.
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