Investigation of the synergic effects of aminoglycoside- fluoroquinolone and third-generation cephalosporin combinations against clinical isolates of Pseudomonas spp.

摘要: Antimicrobial synergy resulting from antibiotic combination therapy is often important in the treatment of serious bacterial infections. Previous studies have demonstrated between an aminoglycoside and ‚-lactam antibiotics Pseudomonas aeruginosa The present paper investigates synergic effects aminoglycosid es (amikacin netilmicin) fluoroquinolones (ciprofloxacin, ofloxacin pefloxacin) with third-generation cephalosporins (cefoperazone, ceftriaxone ceftazidime) against 18 clinical isolates spp. these drugs were examined by three methods (disc diffusion, ‘chequerboard’ titration time‐killing method), to evalu ate activities alone selected isolates. Fractional inhibitory concentration indices calculated for all combinations. Use disc diffusion method revealed that amikacin netilmicin exhibited 7‐12 isolates, whereas combinations quinolones ceftazidime displayed only case 3‐5 On titration, exerted seven other showed fewer but every effect some tested had different various With method, 1 /2 x MIC or ciprofloxacin third-generat ion proved be most effective. No antagonism was found Discrepancies detection observed methods.