Inhibition of the mosquito transmission of Plasmodium berghei by Malarone (atovaquone-proguanil)

摘要: Sera from patients treated with atovaquone-proguanil (Malarone) have previously been shown to inhibit the mosquito transmission of Plasmodium falciparum, though inhibition was not complete and effect declined 2 weeks after treatment. In marked contrast, P. berghei by human sera (fed mosquitoes, gametocytes, via membrane feeders) volunteers total up day 28 post-treatment still very significant at 56. view short half-lives atovaquone proguanil, this unexpected, further experiments, reported here, were undertaken. contrast incomplete blockade infectivity falciparum serum taken 4 days post-treatment, such totally inhibitory against a 1:10,000 dilution, indicating remarkable sensitivity demonstrating an unusual difference between two species in response drug. The on caused mainly through development ookinete oocyst. Despite previous information rapid elimination patients, present data indicate that low concentrations drug may persist plasma for some