Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut.
作者： Meiji Arai , Yasmene I.H. Alavi , Jacqueline Mendoza , Oliver Billker , Robert E. Sinden
DOI: 10.1016/J.EXPPARA.2004.01.002
关键词:
摘要: We studied the transmission-blocking effect of isonicotinic acid hydrazide (INH), a widely used anti-tuberculosis drug, against Plasmodium gallinaceum and berghei. INH-treatment infected animals did not inhibit parasite development in blood vertebrate host, but exflagellation, ookinete formation, oocyst mosquito. Oocyst was inhibited dose-dependent manner. The ED(50) P. gallinaceum/chicken/Aedes aegypti model berghei/mouse/Anopheles stephensi 72 109 mg/kg, respectively. In marked contrast, vitro exflagellation were directly affected by physiological concentrations INH. suggest that INH exerts its inhibitory effects on mosquito stages malaria an indirect, at present undefined mechanism. Further elucidation mechanism how inhibits specifically may allow us to identify new targets for control strategy.
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