Association of Osteoarthritis with Perfluorooctanoate and Perfluorooctane Sulfonate in NHANES 2003–2008

摘要: Background: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent, synthetic industrial chemicals. Perfluorinated compounds linked to health impacts that may be relevant osteoarthritis, cartilage repair, inflammatory responses. Objectives: We investigated whether PFOA PFOS exposures associated with prevalence of associations differ between men women. Methods: used multiple logistic regression estimate serum concentrations self-reported diagnosis osteoarthritis in persons 20–84 years age who participated NHANES during 2003–2008. adjusted for potential confounders including age, income, race/ethnicity. Effects by sex were estimated using stratified models interaction terms. Results: Those the highest exposure quartile had higher odds compared those lowest [odds ratio (OR) = 1.55; 95% CI: 0.99, 2.43; OR 1.77; 1.05, 2.96]. When stratifying sex, we found positive women, but not men. Women quartiles (OR 1.98; 1.24, 3.19 1.73; 0.97, 3.10). Conclusions: Higher was also women only, though effect estimates significant. More research is needed clarify differences susceptibility regard possible effects these other endocrine-disrupting