Heat Shock Protein 27 (HSP27, HSPB1) Is Up-Regulated by Targeted Agents and Confers Resistance to Both Targeted Drugs and Chemotherapeutics
作者： Daniele Musiani , John David Konda , Simona Pavan , Erica Torchiaro , Jessica Erriquez
DOI: 10.1007/978-3-319-17211-8_2
关键词:
摘要: The Heat Shock Protein of 27 kDa (HSP27) is a molecular chaperone with anti-apoptotic properties and role in cytoskeleton stability. Not surprisingly, HSP27 often increased cancers associated poor patients’ survival resistance to conventional chemotherapy. Conversely, the response therapies targeted towards oncogenic kinases was poorly characterized. In this chapter we review findings on both chemotherapeutics drugs pro-metastatic phenotype, focusing where tyrosine kinase receptor encoded by MET oncogene activated, namely, gastric ovarian cancers. inhibition addicted cancer cells triggered increase MEK/ERK dependent manner turn limited effectiveness inhibitors vitro vivo. Furthermore, required for metastasis upon activation vivo modulates sensitivity first line Cisplatin Paclitaxel. Altogether, these suggested that induction agents might impact success it be suitable therapeutic target combination treatments.
springer.com
sci-hub.se 参考文章(20)
John P. Neoptolemos, Keith F. Parsons, Anthony D. Desmond, Alan Woolfenden, Youqiang Ke, Mark Fordham, Andrew R. Dodson, Christopher S. Foster, Philip A. Cornford, Heat shock protein expression independently predicts clinical outcome in prostate cancer. Cancer Research. ,vol. 60, pp. 7099- 7105 ,(2000)
Simona Pavan, Daniele Musiani, Erica Torchiaro, Giorgia Migliardi, Marta Gai, Ferdinando Di Cunto, Jessica Erriquez, Martina Olivero, Maria Flavia Di Renzo, HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor International Journal of Cancer. ,vol. 134, pp. 1289- 1299 ,(2014) , 10.1002/IJC.28464
SE Conroy, PD Sasieni, V Amin, DY Wang, P Smith, IS Fentiman, DS Latchman, Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer. British Journal of Cancer. ,vol. 77, pp. 1875- 1879 ,(1998) , 10.1038/BJC.1998.312
G. Wettstein, P.S. Bellaye, O. Micheau, Ph Bonniaud, Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity? The International Journal of Biochemistry & Cell Biology. ,vol. 44, pp. 1680- 1686 ,(2012) , 10.1016/J.BIOCEL.2012.05.024
B Gibert, E Hadchity, A Czekalla, M-T Aloy, P Colas, C Rodriguez-Lafrasse, A-P Arrigo, C Diaz-Latoud, Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers. Oncogene. ,vol. 30, pp. 3672- 3681 ,(2011) , 10.1038/ONC.2011.73
Pramod Pandey, Rebecca Farber, Atsuko Nakazawa, Shailendra Kumar, Ajit Bharti, Carlo Nalin, Ralph Weichselbaum, Donald Kufe, Surender Kharbanda, Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3 Oncogene. ,vol. 19, pp. 1975- 1981 ,(2000) , 10.1038/SJ.ONC.1203531
Bindi M. Doshi, Lawrence E. Hightower, Juliet Lee, The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock Cell Stress & Chaperones. ,vol. 14, pp. 445- 457 ,(2009) , 10.1007/S12192-008-0098-1
Jean-Marie Bruey, Catherine Paul, Annie Fromentin, Sophie Hilpert, André-Patrick Arrigo, Eric Solary, Carmen Garrido, Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo Oncogene. ,vol. 19, pp. 4855- 4863 ,(2000) , 10.1038/SJ.ONC.1203850
V Baylot, C Andrieu, M Katsogiannou, D Taieb, S Garcia, S Giusiano, J Acunzo, J Iovanna, M Gleave, C Garrido, P Rocchi, OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer Cell Death and Disease. ,vol. 2, ,(2011) , 10.1038/CDDIS.2011.104
Livio Trusolino, Andrea Bertotti, Paolo M. Comoglio, MET signalling: principles and functions in development, organ regeneration and cancer Nature Reviews Molecular Cell Biology. ,vol. 11, pp. 834- 848 ,(2010) , 10.1038/NRM3012