Rodent gene drives for conservation: opportunities and data needs

摘要: Invasive rodents impact biodiversity, human health and food security worldwide. The biodiversity impacts are particularly significant on islands, which the primary sites of vertebrate extinctions where we reaching limits current control technologies. Gene drives may represent an effective approach to this challenge, but knowledge gaps remain in a number areas. This paper is focused what currently known about natural developing synthetic gene drive systems mice, some key areas exist, findings variety disciplines relevant those brief consideration how engagement at regulatory, stakeholder community levels can accompany contribute effort. Our species focus house mouse, Mus musculus, as genetic model system that also important invasive pest. application development intended reduce reproduction potentially eliminate from islands. technologies have potential produce benefits for conservation, security. A broad-based, multidisciplinary necessary assess transparent, responsible manner.