Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.

摘要: Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required traditional procedures. The synthesis was effective also immobilized able to perform for more runs. novel catechols were evaluated against influenza A virus, that continue represent a severe threat worldwide. significant antiviral activity observed characterized antioxidant carbon alkyl side-chains, suggesting the possibility of new inhibition mechanism based on both redox properties.