Characterization of the humanTCAM1Ppseudogene and its activation by a potential dual promoter-enhancer: Comparison with a protein-coding mouse orthologue
作者： Misuzu Kurihara , Atsushi P. Kimura
DOI: 10.1016/J.FEBSLET.2015.01.023
关键词:
摘要: Abstract TCAM1P is a unitary pseudogene, which was disabled since the human–mouse divergence. Here we found that specifically expressed in human testis, with different cell type-specificity from mouse Tcam1, and characterized its transcripts. At locus, multifunctional dual promoter–enhancer (DPE) controls expression of Tcam1 Smarcd2 genes. The corresponding sequence to potentially function as DPE, although molecular mechanism mouse. Interestingly, change DPE activity occurred before pseudogenization TCAM1P. These data suggest presence genome for first time, provide an important model evolutionary changes regulatory pseudogene.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(40)
M Oishi, T Kimura, J Fujiwara, D Ayusawa, A novel regulatory sequence affecting the constitutive expression of tissue plasminogen activator (tPA) gene in human melanoma (Bowes) cells. Journal of Biological Chemistry. ,vol. 269, pp. 18558- 18562 ,(1994) , 10.1016/S0021-9258(17)32345-1
B K Jones, B R Monks, S A Liebhaber, N E Cooke, The human growth hormone gene is regulated by a multicomponent locus control region. Molecular and Cellular Biology. ,vol. 15, pp. 7010- 7021 ,(1995) , 10.1128/MCB.15.12.7010
Atsushi P. Kimura, Stephen A. Liebhaber, Nancy E. Cooke, Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation. Molecular Endocrinology. ,vol. 18, pp. 1018- 1032 ,(2004) , 10.1210/ME.2003-0468
Felice Elefant, Yuhua Su, Stephen A Liebhaber, Nancy E Cooke, Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region The EMBO Journal. ,vol. 19, pp. 6814- 6822 ,(2000) , 10.1093/EMBOJ/19.24.6814
Kunapuli T. Madhusudhan, Sharon S. Naik, Mulchand S. Patel, Characterization of the promoter regulatory region of the human pyruvate dehydrogenase beta gene Biochemistry. ,vol. 34, pp. 1288- 1294 ,(1995) , 10.1021/BI00004A023
Roopa L. Nalam, Yi-Nan Lin, Martin M. Matzuk, Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility. Molecular and Cellular Endocrinology. ,vol. 315, pp. 246- 253 ,(2010) , 10.1016/J.MCE.2009.09.010
IDRISS M. BENNANI-BAITI, BEVERLY K. JONES, STEPHEN A. LIEBHABER, NANCY E. COOKE, Physical linkage of the human growth hormone gene cluster and the skeletal muscle sodium channel alpha-subunit gene (SCN4A) on chromosome 17. Genomics. ,vol. 29, pp. 647- 652 ,(1995) , 10.1006/GENO.1995.9954
Katharina H. Surinya, Timothy C. Cox, Brian K. May, Identification and Characterization of a Conserved Erythroid-specific Enhancer Located in Intron 8 of the Human 5-Aminolevulinate Synthase 2 Gene Journal of Biological Chemistry. ,vol. 273, pp. 16798- 16809 ,(1998) , 10.1074/JBC.273.27.16798
Yuhua Su, Stephen A. Liebhaber, Nancy E. Cooke, The human growth hormone gene cluster locus control region supports position-independent pituitary- and placenta-specific expression in the transgenic mouse. Journal of Biological Chemistry. ,vol. 275, pp. 7902- 7909 ,(2000) , 10.1074/JBC.275.11.7902
E. J. Yoo, N. E. Cooke, S. A. Liebhaber, An RNA-independent linkage of noncoding transcription to long-range enhancer function. Molecular and Cellular Biology. ,vol. 32, pp. 2020- 2029 ,(2012) , 10.1128/MCB.06650-11