Are intestinal helminths risk factors for developing active tuberculosis?
作者： Daniel Elias , Getahun Mengistu , Hannah Akuffo , Sven Britton
DOI: 10.1111/J.1365-3156.2006.01578.X
关键词:
摘要: Summary objectives To determine the prevalence of intestinal helminth infections in active tuberculosis patients and their healthy household contacts to assess its association with TB an area endemic for both types infections. methods Smear-positive pulmonary were tested helminths using direct microscopy formol-ether concentration techniques. Three consecutive stool samples examined before start chemotherapy. Sputum was done sodium hypochlorite Participants also HIV by commercial sandwich enzyme linked immunosorbent assay. results The study population consisted 230 smear-positive 510 contacts. 71% 36% controls. seroprevalence significantly higher than controls (46.7% vs. 11.6%, P < 0.001). Conditional logistic regression analysis showed a strong between infection (OR ¼ 4.2, 95% CI 2.7‐5.9, 0.001), 7.8, 4.8‐12.6, 0.0001). odds being patient increased number species per person: individuals mono-infection it 4.3 (95% 2.8‐6.8); people infected two 4.7 2.5‐8.7), three or more 12.2 (3.9‐52.6). conclusion Intestinal may be one risk factors development addition infection. This finding have important implications control areas world.
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