Developmental Patterns of Doublecortin Expression and White Matter Neuron Density in the Postnatal Primate Prefrontal Cortex and Schizophrenia

摘要: Postnatal neurogenesis occurs in the subventricular zone and dentate gyrus, evidence suggests that new neurons may be present additional regions of mature primate brain, including prefrontal cortex (PFC). Addition to PFC implies local generation or migration from areas such as zone. We examined putative contribution new, migrating postnatal cortical development by determining density white matter subjacent measuring expression doublecortin (DCX), a microtubule-associated protein involved neuronal migration, humans rhesus macaques. found striking decline DCX (human macaque) (humans) during infancy, consistent with arrival early cortex. Considering expansion brain this time, neuron does not necessarily indicate reduced total numbers life. Furthermore, numerous cells deep grey were positive for migration-associated glycoprotein polysialiated-neuronal cell adhesion molecule GAD65/67, suggesting immature adult GABAergic. also mRNA schizophrenia patients (n = 37) matched controls did find any difference expression. However, we report negative correlation between patients, contrast human where are higher earlier Accumulation would congruent support hypothesis deficit schizophrenia.