Transcriptome analysis of male-female differences in prefrontal cortical development.

作者: C S Weickert , M Elashoff , A B Richards , D Sinclair , S Bahn

DOI: 10.1038/MP.2009.5

关键词:

摘要: Human neuropsychiatric disorders that involve the prefrontal cortex show gender differences in age of onset, prevalence and symptomatology. Gender dimorphisms human-brain development may include differential cortical expression genes on both sex chromosomes1, 2 autosomes. Here we identify gene during human illuminate molecular basis biases vulnerability to brain disorders.

参考文章(6)
Laura L. Carruth, Ingrid Reisert, Arthur P. Arnold, Sex chromosome genes directly affect brain sexual differentiation Nature Neuroscience. ,vol. 5, pp. 933- 934 ,(2002) , 10.1038/NN922
John L Rinn, Joel S Rozowsky, Ian J Laurenzi, Petur H Petersen, Kaiyong Zou, Weimin Zhong, Mark Gerstein, Michael Snyder, Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Developmental Cell. ,vol. 6, pp. 791- 800 ,(2004) , 10.1016/J.DEVCEL.2004.05.005
Eiichi Hinoi, Vladimir J Balcar, Nobuyuki Kuramoto, Noritaka Nakamichi, Yukio Yoneda, Nuclear transcription factors in the hippocampus. Progress in Neurobiology. ,vol. 68, pp. 145- 165 ,(2002) , 10.1016/S0301-0082(02)00078-3
Hanga C Galfalvy, Loubna Erraji-Benchekroun, Peggy Smyrniotopoulos, Paul Pavlidis, Steven P Ellis, J John Mann, Etienne Sibille, Victoria Arango, Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction. BMC Bioinformatics. ,vol. 4, pp. 37- 37 ,(2003) , 10.1186/1471-2105-4-37
Loubna Erraji-Benchekroun, Mark D. Underwood, Victoria Arango, Hanga Galfalvy, Paul Pavlidis, Peggy Smyrniotopoulos, J. John Mann, Etienne Sibille, Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biological Psychiatry. ,vol. 57, pp. 549- 558 ,(2005) , 10.1016/J.BIOPSYCH.2004.10.034
Marquis P Vawter, Simon Evans, Prabhakara Choudary, Hiroaki Tomita, Jim Meador-Woodruff, Margherita Molnar, Jun Li, Juan F Lopez, Rick Myers, David Cox, Stanley J Watson, Huda Akil, Edward G Jones, William E Bunney, None, Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes Neuropsychopharmacology. ,vol. 29, pp. 373- 384 ,(2004) , 10.1038/SJ.NPP.1300337